From Montréal
Highway 20 east up to Québec City
In Québec City, take Highway 73 north to highway 440 east
Highway 440 east to Route 138 east
Route 138 east up to Sept-Îles (Route 138 becomes Laure Blvd in Sept-Îles)

From Québec City
Highway 73 north to highway 440 east
Highway 440 east to Route 138 east
Route 138 east up to Sept-Îles (Route 138 becomes Laure Blvd in Sept-Îles)

From Chicoutimi
Highway 172 to Route 138 east
Route 138 east up to Sept-Îles (Route 138 becomes Laure Blvd in Sept-Îles)

From Ottawa
Trans Canada 417 east (Ontario) to highway 40 east (Québec)
Highway 40 east to highway 25 south
Highway 25 south to highway 20 east
Highway 20 east up to Québec City
From Québec City, highway 73 north to highway 440 east
Highway 440 east to Route 138 east
Route 138 east up to Sept-Îles (Route 138 becomes Laure Blvd in Sept-Îles)

From Toronto
Route 404 north to highway 401 east
Highway 401 east (Ontario) becomes highway 20 east (Québec)
Highway 20 east to highway 13 north
Highway 13 north to highway 40 east
Highway 40 east to highway 25 south
Highway 25 south to highway 20 east
Highway 20 east up to Québec City
From Québec City, highway 73 north to highway 440 east
Highway 440 east to Route 138 east
Route 138 east up to Sept-Îles (Route 138 becomes Laure Blvd in Sept-Îles)