From Montréal:

Highway 20 east, direction Québec City
Take the “Pont Pierre-Laporte” exit
Take the “Avenue des Hôtels” exit, just after exiting the bridge
Follow the indications for “Avenue des Hôtels” 
Holiday Inn Express Quebec is to your right. 

Highway 40 east, direction Québec City
Take the “Autoroute Duplessis (540) south” exit
Take the “Pont de Québec/Chemin St-Louis” exit
Take the “Avenue des Hôtels” exit
Turn left at the traffic lights, proceed to the second traffic lights and then turn left  
Holiday Inn Express Quebec is located to your right. 

From: Eastern Quebec and New Brunswick:

Highway 20 west, direction Québec City
Take the “Pont Pierre-Laporte” exit
Take the “Avenue des Hôtels” exit just after exiting the bridge
Follow the indications for “Avenue des Hôtels”
Holiday Inn Express Quebec is located to your right. 

From: The Beauce and Maine (USA)

Highway 73 north, direction Québec City
Take the “ Pont Pierre-Laporte” exit
Take the “ Avenue des Hôtels” exit just after exiting the bridge
Follow the indications for “Avenue des Hôtels” 
Holiday Inn Express Quebec is located to your right.